There is an increasing demand for accurate, efficient and cost-effective treatment methods and devices in critical care units. The main goal behind the research in Nanobios Lab at IIT Bombay relates to the development of biosensor assays and their integration into affordable Point-of-care diagnostic devices. Nanobios lab in collaboration with Biosense Technologies Pvt Ltd have already commercialized, uChek (http://uchek.in) - a low cost smartphone based urine dipstick reader which was designed, tested and deployed. uChek can interpret upto ten analytes in urine including glucose, bilirubin , ketones, proteins, urobilinogen, pH, SG, occult blood, leukocytes and nitrites. The accuracy of uChek was found to be comparable to commercially available semi-automated urinalysis instruments in laboratories with 100% of readings within +/- 1 color block. uChek was launched on 28 April 2013 in India and the United States and there are around 1000 uChek systems operational across the world. Nanobios lab in collaboration with Biosense Technologies Pvt Ltd have also manufactured and commercialized "SuChek". Suchek is an indigenous, accurate, low-cost glucometer supported by the Indian Council of Medical Research. Suchek reagent strips are as accurate as conventional glucometers, at a fraction of the price. Along with the glucometer, the companion Suchek mobile application helps save, trend and analyze blood glucose levels at an individual level or track response to treatment at a community level. The reader and strips are currently under clinical trials at various hospitals in India. Our lab is also working on fabricating microneedles for vaccine delivery. A micron-scale out-of-plane hollow cylindrical Si structure defines our microneedle. These hollow pointed micron scale devices can pierce skin and deliver a drugs or compounds. Microneedles penetrate through the stratum corneum (the outermost layer of the skin with a thickness of up to 20 ?m) and deliver the drug directly underneath it. Thus as a result, microneedles increase skin permeability to several hydrophilic and lipophilic compounds, and therefore can potentially allow administration of a much wider range of drugs. The promising scope of microneedles with sparse dose requirement and painless trans-epidermal delivery of vaccines with better patient compliance can be evidently realized from the current mechanical and biological studies carried out with model drug. Low cost production, simple storage, handling and distribution may promote use of microneedles in mainstream healthcare. We believe that these are small steps towards “Make in India and Made in India” and a lot more needs to be done to educate everyone of the importance of making healthcare affordable in India.