This course has been initiated to introduce students to biosensors and microfabricated systems for biosensing, primarily on silicon so that they can get on with their seminars and projects in these areas. The focus of this course would be to acquaint students to devise structures, analysis of the structures to obtain device characteristics, and finally approaches to design and test these devices and systems. Pre-requisite: Introductory courses on device physics & differential equations. If the first-level course on devices has not been taken, students should get an introduction to the area by reading a book such as Semiconductor Devices: Physics & Technology by SM Sze [John Wiley, 2002]. The broad structure of the course would be: Weeks 1-2: Approaches to designing electronic systems Sensor classification & sensing principles Introduction to biosensors & bioMS Weeks 3-6: Semiconductor sensors for physical measurands Physicochemical sensors integrable on silicon Weeks 7-9:Biosensors: Structures & device analysis Catalytic biosensors Affinity biosensors Weeks 10-12: bioMS: Architectures & analytic models.